Larissa (Greek: ??????, Lárisa) is a city of the Thessaly periphery of Greece, and capital of the Larissa Prefecture. It is a principal agricultural centre and a national transportation hub, linked by rail with the port of Volos and with Thessaloniki and Athens. The population of the greater area is around 250,000, and takes in the Municipalities of Nikaia, Giannouli and other smaller suburban communities. According to archaeological evidence, the capital of Thessaly, Larissa, lies atop a site that has been inhabited since the tenth millennium before Christ. A major commercial and industrial centre, Larissa sits in the middle of the plain of Thessaly, a few kilometers off the Athens-Thessaloniki National Road. Legend has it that Hippocrates, the Father of Medicine, died here.   Wikipedia